Description: Dilated cardiomyopathy (DCM) is an inherited heart disorder. DCM is a primary myocardial disease that can lead to the development of congestive heart failure and sudden cardiac death. In affected dogs, the heart muscle is weak, and the ventricles are dilated with thin walls. These enlarged hearts have poor contractility and are prone to arrhythmias. Affected dogs show clinical signs of poor heart function between 1 and 8 years of age. Affected dogs develop clinical signs ranging from mild exercise intolerance to sudden death or congestive heart failure as they age. Symptoms of heart disease include exercise intolerance, fatigue, cough, difficulty breathing, rapid breathing, fainting, and sudden death. Affected dogs that do not die suddenly of arrhythmias usually die of congestive heart failure by around 7 years of age.
Inheritance: autosomal recessive
Mutation: chr28:22146844-22146865 (canFam3), c.2472_2493del: 22 bp deletion in RBM20 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes
The analysis is suitable for the following breeds: Giant Schnauzer, Standard Schnauzer