Description: Factor VII (FVII) is a vitamin K dependent glycoprotein that is synthesized in the liver. It plays a key role in initiating haemocoagulation. In the case of injury of FVII vessels in combination with tissue factor (TF) and in the presence of calcium, factor IX and factor X cleave into their active forms, which are involved in the formation of thrombin. Factor VII deficiency adversely affects blood clotting and causes excessive bleeding in the event of any injury or surgery.
Inheritance: autosomal recessive
Mutation: c.6385G>A (Gly96Glu) in EGF-2 domain of the cFVII gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Airedale, Alaskan Klee Kai, Beagle, Giant Schnauzer and Scottish Deerhound