Description: Characteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, a predominance of type I fibers, and aberrant cell positioning of nuclei and mitochondria. In Great Danes, generalized muscle atrophy, exercise intolerance, exercise-induced tremor, and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18 months of age due to severe debilitating muscle weakness.
Inheritance: autosomal recessive
Mutation: BIN1 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Great Dane
Notes: The analysis is performed by partner lab EVG (Maribor), https://eurovetgene.com/sl/. The invoice is issued by Slovgen. The payment is in advance. The result is sent to the customer from EVG lab. The analysis can be ordered in Slovgen lab or directly in EVG lab.
