Description: Progressive retinal atrophy (PRA) in dogs is a group of genetically heterogeneous retinal disorders. PRA is characterized by a very rapid loss of rod function followed by loss of cone function, ie progressive degeneration and cell death of the photoreceptors. The affected dogs have a primary loss of rod photoreceptor cells followed by a loss of cone function. The first clinical symptoms appear as poor lighting conditions. The disease progresses very slowly, and affected dogs appear to be visually normal throughout their lives because the cone function is relatively well preserved. This is followed by a gradual loss of vision at night and then in daylight, leading to blindness. The onset of the disease is from 5 to 6 years of age.
Inheritance: autosomal recessive
Mutation: c.2685delA2687_2688insTAGCTA in CNGB1gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. Pre oficiálne účely odporúčame odber veterinárom, ktorý súčasne overí a potvrdí identitu jedinca do tlačiva.
The analysis is suitable for the following breeds: Pappilons, Phalens
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