Description: Isolated lentis ectopia, known as primary lens luxation, is a serious eye disease that can result in blindness. The lens of the eye is dislocated as a result of damage to the suspensory apparatus, which keeps it fixed in the fossa hyaloidea (lens fossa on the front side of the vitreous). Dislocation can also occur as a result of an accident. The hereditary form is caused by a defect fixation of the lens zonules or suspensory fibers, resulting in glaucoma and loss of vision. PLL occurs with a high frequency in several terrier breeds and in some other breeds where terrier is likely to have occurred as an ancestor. Abnormalities in the ultrastructure of zonal fibers are already apparent at the age of 20 months, long before the onset of dislocation, which usually occurs when dogs are 3 to 8 years old.
Inheritance: autosomal recessive
Mutation: c.1473+1G>A in ADAMTS17 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Australian cattle dog, Chinese Crested dog, Fox terrier, Jack Russel Terriere, Jagdterrier, Lancashire Heelers, Miniature bull Terrier, Parson Russel Terriere, Patterdale Terrier, Rat Terrier, Sealyham Terrier, Tibetan Terrier, Toy Fox Terrier, Volpino Italiano, Welsh Terrier, Yorkshire
Notes: PLL has been diagnosed in more than 17 dog breeds and mainly affects terriers and related breeds
