Description: Persistent Müller’s syndrome (PMDS) is an inherited disorder of sexual development that affects male dogs. In males with this disorder, some female reproductive organs also develop. Affected males may also have a uterus, fallopian tubes, ectocervix, and part of the vagina that extends to the prostate gland. About half of the affected male dogs have externally normal testicles and are fertile, but internally have female reproductive organs, including the uterus. In addition to the remnants of female reproductive structures, another 50% of affected males also have unilateral or bilateral cryptorchidism (undescended testicles into the sac). As a result, there is a predisposition to infertility and an increased risk of testicular cancer. This condition is often accompanied by inflammation, e.g. pyometra (infection in the uterus) and accompanying phenomena – polydipsia, polyuria, and loss of appetite.
Females with this mutation have a normal internal and external female anatomy
Inheritance: autosomal recessive
Mutation: c.241C> T (p.R81 *) in AMHR2 gene (chr27:1794738 (canFam3): C>T)
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes
The analysis is suitable for the following breeds: Miniature Schnauzer, Schnoodle, Standard Schnauzer