Description: Progressive retinal atrophy (PRA) is a hereditary disease that occurs in many dog breeds and manifests in various clinically unrecognizable forms. The progressive degeneration of the rods and cones in the retina leads to a progressive loss of vision, which results in complete blindness. RCD4 is a form of PRA that was first described by Gordon Setters and later found in several other dog breeds. Gradual degeneration of photoreceptor cells is typical. The mean age of onset is 10 years, cases were observed at the age of 5 to 12 years.
Inheritance: autosomal recessive
Mutation: c.3149_3150insC in C2orf71 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Australian Cattle Dog, Australian Stumpy Tail Cattle Dog, Cockapoo, English Setter, Gordon Setter, Irish Setter, Irish Red Setter, Irish Red & White Setter, Japanese Spitz, Old Danish Pointing Dog, Polish Lowland Sheepdog, Small Munsterlander, Tatra Shepherd Dog, Tibetan Terrier, Poodle (all)
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