Description: In dogs, there are three basic characteristics of hair: length (FGF5), presence of eyebrows and mustaches – furnishing (RSPO2) and the presence of wavy or curly hair (KRT71). Curly or wavy hair is a dominant characteristic and are caused by two separate known mutations in the KRT71 gene. Based on the results of a genome-wide association study (Cadieu et al. 2009), a correlation was found between curly hair and the presence of the T allele in SNP at position 5.542.806, with the dominant T allele. This SNP polymorphism is located on CFA27 in a cluster of genes encoding keratin (KRT71). Thus, the T allele in the KRT71 gene is associated with the curly hair phenotype and is dominant, meaning that both the TT and CT genotypes determine the curly hair phenotype. Dogs with a non-curly type of hair have the genotype CC.
Inheritance: autosomal recessive
Mutation: c.451C>T in KRT71 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Airedale Terrier, American Water Spaniel, Bichon Frise, Border Collie, Boykin Spaniel, Chesapeake Bay Retriever, Chihuahua, Dachshund, Havanese, Kerry Blue Terrier, Kuvasz, Leonberger, Maltese, Pharaoh Hound, Portuguese Water Dog, Soft Coated Wheaten Terrier, Welsh Terrier, Wire Fox Terrier
Notes: We do not analyze the new mutation: Variant C2 c.1266_1273delinsACA in the KRT71 gene. It is believed that the C2/C2 variant, in addition to the curly hair, is a genetic risk factor for follicular dysplasia in some breeds.