Description: Improper coat (IC) or non-standard hair is another manifestation of the insertion in the RSPO2 gene in some dog breeds. Improper coat (IC) is inherited in autosomal recessive. The mutation is the insertion of 167 bp in the untranslated region (UTR) of RSPO2.
In the Portuguese Water Dogs (PWD), there are two coat variants: wavy and curly. In this breed, however, there may be individuals who do not have a coat according to the standard – Improper Coat (IC). IC is characterized by short hair on the head, face and legs. The body is covered with a thick and rather straight or slightly wavy coat and looks similar to a flat- or curly-coated retriever.
Dogs with standard coat have one or both alleles with insertion. The non-standard coat (IC) has an autosomal recessive inheritance and thus only occurs when an individual has the wild-type allele from both parents (it is homozygous for the wild-type allele). Heterozygous individuals are carriers of the wild-type allele. The genetic test is able to detect carrier dogs in the litter and by the targeted selection of individuals for mating, it is possible to avoid the presence of offspring with wild-type alleles in the homozygous state (individuals with the non-standard coat -IC).
Inheritance: autosomal recessive
Mutation: insertion 167 bp in 3´UTR region in RSPO2 gene
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Havana silk dog – Bichone Havanese, Goldendoodle, Labradoodle, Portuguese Water Dog
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