Description: Juvenile renal dysplasia (JRD) is defined as the abnormal development of kidney cells that do not develop properly during embryogenesis. JRD is a fatal disease that results in end-stage renal failure and subsequent death. The enzyme in the synthesis of prostaglandins – Cox-2 plays an important role in this disease. Prostaglandins require activation by inflammatory or other stimuli.
Individuals whose kidneys are abnormally developed have many symptoms. In general, one or more of the following symptoms occur:
• Increased production and excretion of large volumes of urine (polyuria, usually between 6 and 24 months of age)
• Increased thirst or excessive water intake (polydipsia, usually between 6 and 24 months of age)
• Blood in the urine (haematuria)
• Reducing the effect of sex hormones (anestrus)
• Lack of appetite (loss of appetite, anorexia)
• Poor growth (dwarfism)
• Weight loss
There is no specific treatment for dogs suffering from JRD. The treatment is the same as in chronic kidney failure for any reason
Inheritance: autosomal dominant with incomplete penetrance
Mutation: Cox-2 promotor (4 mutant allelic variants)
Sample: EDTA whole blood (1.0 ml) or 2 buccal brushes. For official purposes, the confirmation of the dog’s identity by Veterinarian is recommended.
The analysis is suitable for the following breeds: Airedale Terrier, Alaskan Malamute, Bedlington Terrier, Beagle, Bobtail, Boxer, Bulldog, Chow Chow, Collie, Dobermann, Golden retriever, Great Dane, Hamiltonstövare, Irish Soft Coated Wheaten Terrier, Irish Wolfhound, Keeshond, King Charles Spaniel, Lhasa apso, Norwegian Elkhound, Portuguese Water Dog, Poodle, Samoyed, Schnauzer Miniature, Shitzu, Yorkshire Terrier, etc.
Notes: Renal dysplasia is inherited autosomal dominantly, which means, one copy of the mutation is sufficient to develop the disease. An animal is at risk of developing RD if it has one or two copies of the mutated gene.